Prof. Ling-Ling Chen
Principal Investigator (Lab Head)
E-mail: linglingchen@sibcb.ac.cn
Ling-Ling Chen carried out doctoral and post-doctoral work at the UConn Health, USA from 2004 to 2010. She also completed an MBA degree at the UConn Business School in 2009 and was promoted to Assistant Professor in Residence at UConn in 2010. Chen moved to Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS) as an independent PI in 2011. She was selected as a Howard Hughes Medical Institute (HHMI) International Research Scholar in 2017, and as a New Cornerstone Investigator in 2022. She has been appointed as the Associate Director, State Key Laboratory of Molecular Biology since 2017, and as the Director of the Key Laboratory of RNA Innovation, Science and Engineering, CAS since 2022. Her research has made important contributions to our understanding of the diversity, biogenesis and function of long coding RNAs (lncRNAs), in particular, the biogenesis of circular RNAs and their impact on innate immunity, and the snoRNA-related lncRNAs in the assembly and function of nuclear bodies.
Education and Training
| 2004-2009 | PhD, Biomedical Science, University of Connecticut Health, USA with Gordon Carmichael |
| 2007-2009 | MBA, Management, University of Connecticut, Business school, USA |
| 2000-2003 | M.S., Pharmacology, Shanghai Institute of Materia Medica, CAS, China |
| 1996-2000 | B.S., Biology, Lanzhou University, China |
Professional Positions
| 2011- | Principal Investigator, CEMCS, SIBCB, CAS, China | ||
| 2010-2011 | Asst. Prof. in Residence, Dept. of Genet & Dev Biol, UConn Health, USA | ||
| 2009-2010 | Postdoctoral Fellow, UConn Health, USA with Gordon Carmichael | ||
Institutional Responsibilities
| 2023- | Director, Key Laboratory of RNA Innovation, Science and Engineering (RISE), CAS, China |
| 2017-2023 | Associate Director, State Key Laboratory of Molecular Biology, CAS, China |
Selected Professional Activities (Current)
| 2019-2027 | Director, Gene Regulation, Chinese Society of Biochemistry and Molecular Biology |
| 2021- | Associate Editor, RNA |
| 2020- | Advisory Board, Cell |
| 2020- | Board of Reviewing Editor, Science |
| 2020- | Advisory Board, Mol Cell |
| 2020- | Advisory Board, Cell Chem Biol |
| 2020- | Advisory Board, Trends Biochem Sci |
| 2020- | Advisory Board, Trends Cell Biol |
| 2015- | Advisory Board, Trends in Genetics |
| 2014- | Editorial Board, Genome Biology |
| 2017- | Specialist Advisor on lncRNA genes for the HUGO Gene Nomenclature Committee |
| 2019-2021 | Meetings Committee and Nomination Committee, the RNA Society |
Selected Prizes, Awards, Honors
| 2024 | Second Prize of National Natural Science Award |
| 2024 | FAOBMB Award for Research Excellence |
| 2023 | Shanghai Outstanding Talents |
| 2022 | New Cornerstone Investigator |
| 2021 | RNA Society Mid-Career Research Award |
| 2020 | Science and Technology Award for Young Scientists of China |
| 2020 | Xplorer Prize |
| 2017 | Howard Hughes Medical Institute (HHMI) International Research Scholar |
| 2017 | C.C. Tan (Jia-Zhen Tan) Life Science Award |
| 2017 | Promega Innovation Award for Cell Biology |
| 2016 | Chinese Biological Investigators Society (CBIS) Young Investigator Award |
| 2016 | Asian-Pacific Molecular Biology Network (A-IMBN) Research Young Investigator Award |
| 2016 | Shanghai Science and Technology Elite Award |
| 2016 | L’OREAL China for Women in Science |
Selected Co-organization of International Meetings
| 2024 | Federation of American Societies for Experimental Biology (FASEB) Conference on Nuclear Bodies: Hubs of Genomic Activity |
| 2024 | Cold Spring Harbor Laboratory (CSHL) Conference on Regulatory & Non-coding RNAs |
| 2023 | The 28th Annual Meeting of the RNA Society |
| 2022 | Cold Spring Harbor Laboratory (CSHL) Conference on Regulatory & Non-coding RNAs |
| 2022 | Cold Spring Harbor Asia (CSHA) Conference on RNA Biology |
| 2021 | Keystone Symposium on Non-Coding RNAs |
| 2021 | Noncoding RNA World: From Mechanism to Therapy |
| 2021 | Japanese Society for Developmental Biology/Asia-Pacific Developmental Biology Network |
| 2020 | The 25th Annual Meeting of the RNA Society |
| 2020 | Cold Spring Harbor Laboratory (CSHL) Conference on Regulatory & Non-coding RNAs |
| 2018 | Cold Spring Harbor Asia (CSHA) Conference on RNA Biology |
Selected Invited Plenary and Keynote Lectures
| 2024 | Cell Symposia on Functional RNAs, Beijing, China (Keynote) |
| 2024 | National Academic Conference of CSBMB, Changsha, China (Keynote) |
| 2024 | Non-coding RNA World 2024: Exploring Mechanisms, Designing Medicines, Basel, Switzerland 2024 (Keynote) |
| 2024 | Sydney RNA Salon, Australia (Keynote) |
| 2024 | RNA Symposium: Nature’s Unsolved Puzzles, Singapore (Keynote) |
| 2023 | The Non-Coding Genome, the EMBO | EMBL Symposium, Heidelberg, Germany (Keynote) |
| 2023 | Keystone Symposia on Biomolecular Condensates: Emerging Cellular and Biophysical Roles/Protein-RNA Interactions, Vancouver, Canada (Plenary) |
| 2023 | Cold Spring Harbor Meeting on Eukaryotic mRNA Processing, USA (Keynote) |
| 2022 | The 7th Annual Meeting of the Danish RNA Society: From Basic Research to Industrial Applications (virtual), Denmark (Keynote) |
| 2022 | CSHL Regulatory & Non-coding RNAs Meeting (in hybrid), Cold Spring Harbor, USA (Keynote) |
| 2022 | Australasian RNA Biology and Biotechnology Conference (in hybrid), Australia (Keynote) |
| 2021 | National Meeting on Phase Separation, Shenzhen, China (Keynote) |
| 2019 | Australian Society of Biochemistry and Molecular Biology, Perth, Australia (Plenary) |
| 2018 | The International Meeting of Biophysics, Chengdu, China (Keynote) |
| 2017 | International Society of Stem Cell Research Annual Meeting, Boston, USA (Plenary) |