Ling-Ling Chen
Principal Investigator (Lab Head)
E-mail: linglingchen@sibcb.ac.cn
Ling-Ling Chen carried out doctoral and post-doctoral work at the UConn Health, USA from 2004 to 2010. She also completed an MBA degree at the UConn Business School in 2009 and was promoted to Assistant Professor in Residence at UConn in 2010. Chen moved to Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS) as an independent PI in 2011. She was selected as a Howard Hughes Medical Institute (HHMI) International Research Scholar in 2017, and as a New Cornerstone Investigator in 2022. She has been appointed as the Associate Director, State Key Laboratory of Molecular Biology since 2017, and as the Director of the Key Laboratory of RNA Innovation, Science and Engineering, CAS since 2022. Her research has made important contributions to our understanding of the diversity, biogenesis and function of long coding RNAs (lncRNAs), in particular, the biogenesis of circular RNAs and their impact on innate immunity, and the snoRNA-related lncRNAs in the assembly and function of nuclear bodies.
Education and Training
2004-2009
PhD, Biomedical Science, University of Connecticut Health, USA with
Gordon Carmichael
2007-2009
MBA, Management, University of Connecticut, Business school, USA
2000-2003
M.S., Pharmacology, Shanghai Institute of Materia Medica, CAS,
China
1996-2000
B.S., Biology, Lanzhou University, China
Professional Positions
2011-
Principal Investigator, CEMCS, SIBCB, CAS, China
2010-2011
Asst. Prof. in Residence, Dept. of Genet & Dev Biol, UConn Health,
USA
2009-2010
Postdoctoral Fellow, UConn Health, USA with Gordon Carmichael
Institutional Responsibilities
2025-
Director, State Key Laboratory of RNA Innovation, Science and Engineering (RISE), CAS, China
2022-2025
Director, Key Laboratory of RNA Innovation, Science and Engineering (RISE), CAS, China
2017-2022
Associate Director, State Key Laboratory of Molecular Biology, CAS,
China
Selected Professional Activities (Current)
2019-2027
Director, Gene Regulation, Chinese Society of Biochemistry and
Molecular Biology
2021-
Associate Editor, RNA
2020-
Advisory Board, Cell
2020-
Board of Reviewing Editor, Science
2020-
Advisory Board, Mol Cell
2020-
Advisory Board, Cell Chem Biol
2020-
Advisory Board, Trends Biochem Sci
2020-
Advisory Board, Trends Cell Biol
2015-
Advisory Board, Trends in Genetics
2014-
Editorial Board, Genome Biology
2017-
Specialist Advisor on lncRNA genes for the HUGO Gene Nomenclature
Committee
2019-2021
Meetings Committee and Nomination Committee, the RNA Society
Selected Prizes, Awards, Honors
2024
Second Prize of National Natural Science Award
2024
FAOBMB Award for Research Excellence
2023
Shanghai Outstanding Talents
2022
New Cornerstone Investigator
2021
RNA Society Mid-Career Research Award
2020
Science and Technology Award for Young Scientists of China
2020
Xplorer Prize
2017
Howard Hughes Medical Institute (HHMI) International Research
Scholar
2017
C.C. Tan (Jia-Zhen Tan) Life Science Award
2017
Promega Innovation Award for Cell Biology
2016
Chinese Biological Investigators Society (CBIS) Young Investigator
Award
2016
Asian-Pacific Molecular Biology Network (A-IMBN) Research Young
Investigator Award
2016
Shanghai Science and Technology Elite Award
2016
L’OREAL China for Women in Science
Selected Co-organization of International Meetings
2024
Federation of American Societies for Experimental Biology (FASEB)
Conference on Nuclear Bodies: Hubs of Genomic Activity
2024
Cold Spring Harbor Laboratory (CSHL) Conference on Regulatory &
Non-coding RNAs
2023
The 28th Annual Meeting of the RNA Society
2022
Cold Spring Harbor Laboratory (CSHL) Conference on Regulatory &
Non-coding RNAs
2022
Cold Spring Harbor Asia (CSHA) Conference on RNA Biology
2021
Keystone Symposium on Non-Coding RNAs
2021
Noncoding RNA World: From Mechanism to Therapy
2021
Japanese Society for Developmental Biology/Asia-Pacific
Developmental Biology Network
2020
The 25th Annual Meeting of the RNA Society
2020
Cold Spring Harbor Laboratory (CSHL) Conference on Regulatory &
Non-coding RNAs
2018
Cold Spring Harbor Asia (CSHA) Conference on RNA Biology
Selected Invited Plenary and Keynote Lectures
2024
Cell Symposia on Functional RNAs, Beijing, China (Keynote)
2024
National Academic Conference of CSBMB, Changsha, China (Keynote)
2024
Non-coding RNA World 2024: Exploring Mechanisms, Designing
Medicines, Basel, Switzerland 2024 (Keynote)
2024
Sydney RNA Salon, Australia (Keynote)
2024
RNA Symposium: Nature’s Unsolved Puzzles, Singapore (Keynote)
2023
The Non-Coding Genome, the EMBO | EMBL Symposium, Heidelberg,
Germany (Keynote)
2023
Keystone Symposia on Biomolecular Condensates: Emerging Cellular
and Biophysical Roles/Protein-RNA Interactions, Vancouver, Canada (Plenary)
2023
Cold Spring Harbor Meeting on Eukaryotic mRNA Processing, USA
(Keynote)
2022
The 7th Annual Meeting of the Danish RNA Society: From
Basic
Research to Industrial Applications (virtual), Denmark (Keynote)
2022
CSHL Regulatory & Non-coding RNAs Meeting (in hybrid), Cold Spring
Harbor, USA (Keynote)
2022
Australasian RNA Biology and Biotechnology Conference (in hybrid),
Australia (Keynote)
2021
National Meeting on Phase Separation, Shenzhen, China (Keynote)
2019
Australian Society of Biochemistry and Molecular Biology, Perth,
Australia (Plenary)
2018
The International Meeting of Biophysics, Chengdu, China (Keynote)
2017
International Society of Stem Cell Research Annual Meeting, Boston,
USA (Plenary)